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. 2014 Jan 30;5:10. doi: 10.3389/fimmu.2014.00010

Table 3.

The number of footprints found in various regions of human VH genes.

Footprint Sequences FR CDR FR1 FR2 FR3 CDR1 CDR2 CDR3
TGAGA 131 212 12 94 118 3 3 6
CTAGAGA 8 8 8
CGAAAGA 9 9 9
CTAGA 28 17 16 17 1 1 14
TACGG 9 5 4 1 4 1 1 2
CAAAA 45 41 13 41 9 4
CTAGGGA 2 1 1 1 1
CAACA 55 33 27 1 5 27 2 23 2
CAAGA 150 149 18 4 145 3 15
CACACAGA 20 20 6 20 6
CGAGACA 7 7 7
CGAGAAA 3 3 3
TGAAAGA 2 2 2
TGAAACA 3 3 2 1
CGAGAGG 8 2 6 2 6
CGAGAGA 86 86 86
CACGG 179 178 6 178 6
CGAGATA 3 3 3
CGAAA 11 11 1 10
TGAAA 61 79 7 33 46 1 3 3
CACACAGAC 20 20 5 20 5
CGAGA 130 3 127 1 2 127
CACACAGACC 20 20 1 20 1
TGAGAAA 6 6 3 3
CAAAAGATA 3 3 3
CGGCAGA 2 2 2
TGAGAGA 3 1 2 1 2
CCAGATATA 2 2 2
CAAGATA 1 1 1
CCAGAGA 84 80 4 80 4
CACGGATAC 5 5 5
CAAGAGA 27 19 8 19 8

Two hundred and thirty-four functional germline human VH alleles were downloaded from the IMGT database (54). For each footprint, the number of times that footprint was found in the VH alleles was recorded. The first column lists the footprint, the second column lists the number of alleles in which the footprint is found. Some alleles contain more than one footprint. The remaining columns indicate how many footprints were found in each of the corresponding regions of the V region. FR, framework; CDR, complementarity determining region. The columns named FR and CDR provide the total number of times that a particular footprint is found in the FR or the CDR.