Table 3.
The number of footprints found in various regions of human VH genes.
| Footprint | Sequences | FR | CDR | FR1 | FR2 | FR3 | CDR1 | CDR2 | CDR3 |
|---|---|---|---|---|---|---|---|---|---|
| TGAGA | 131 | 212 | 12 | 94 | 118 | 3 | 3 | 6 | |
| CTAGAGA | 8 | 8 | 8 | ||||||
| CGAAAGA | 9 | 9 | 9 | ||||||
| CTAGA | 28 | 17 | 16 | 17 | 1 | 1 | 14 | ||
| TACGG | 9 | 5 | 4 | 1 | 4 | 1 | 1 | 2 | |
| CAAAA | 45 | 41 | 13 | 41 | 9 | 4 | |||
| CTAGGGA | 2 | 1 | 1 | 1 | 1 | ||||
| CAACA | 55 | 33 | 27 | 1 | 5 | 27 | 2 | 23 | 2 |
| CAAGA | 150 | 149 | 18 | 4 | 145 | 3 | 15 | ||
| CACACAGA | 20 | 20 | 6 | 20 | 6 | ||||
| CGAGACA | 7 | 7 | 7 | ||||||
| CGAGAAA | 3 | 3 | 3 | ||||||
| TGAAAGA | 2 | 2 | 2 | ||||||
| TGAAACA | 3 | 3 | 2 | 1 | |||||
| CGAGAGG | 8 | 2 | 6 | 2 | 6 | ||||
| CGAGAGA | 86 | 86 | 86 | ||||||
| CACGG | 179 | 178 | 6 | 178 | 6 | ||||
| CGAGATA | 3 | 3 | 3 | ||||||
| CGAAA | 11 | 11 | 1 | 10 | |||||
| TGAAA | 61 | 79 | 7 | 33 | 46 | 1 | 3 | 3 | |
| CACACAGAC | 20 | 20 | 5 | 20 | 5 | ||||
| CGAGA | 130 | 3 | 127 | 1 | 2 | 127 | |||
| CACACAGACC | 20 | 20 | 1 | 20 | 1 | ||||
| TGAGAAA | 6 | 6 | 3 | 3 | |||||
| CAAAAGATA | 3 | 3 | 3 | ||||||
| CGGCAGA | 2 | 2 | 2 | ||||||
| TGAGAGA | 3 | 1 | 2 | 1 | 2 | ||||
| CCAGATATA | 2 | 2 | 2 | ||||||
| CAAGATA | 1 | 1 | 1 | ||||||
| CCAGAGA | 84 | 80 | 4 | 80 | 4 | ||||
| CACGGATAC | 5 | 5 | 5 | ||||||
| CAAGAGA | 27 | 19 | 8 | 19 | 8 |
Two hundred and thirty-four functional germline human VH alleles were downloaded from the IMGT database (54). For each footprint, the number of times that footprint was found in the VH alleles was recorded. The first column lists the footprint, the second column lists the number of alleles in which the footprint is found. Some alleles contain more than one footprint. The remaining columns indicate how many footprints were found in each of the corresponding regions of the V region. FR, framework; CDR, complementarity determining region. The columns named FR and CDR provide the total number of times that a particular footprint is found in the FR or the CDR.