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. 2014 Jan 30;8:5. doi: 10.3389/fnint.2014.00005

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Copyright © 2014 McCool, Christian, Fetzer and Chappell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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α-methyl-5HT suppresses BLA principal neuron excitability via increasing threshold for action potential initiation. (A) Exemplar traces illustrating the decrease in excitability following α-m5HT application in a BLA principal neuron. The traces were generated with identical hyperpolarizing and depolarizing current injections under control (standard aCSF) and ~10 min after drug treatment. Calibration bars: x = 10 ms, y = 10 mV. (B) α-m5HT significantly increased the membrane potential threshold required to generate an action potential in BLA principal neurons. *P < 0.01, paired t-test, n = 8. (C) α-m5HT caused a modest but significant hyperpolarization of the resting membrane potential. *P < 0.05, paired t-test. (D) α-m5HT did not alter the membrane response to a hyperpolarizing current injection.