Table 2.
Top 10 hub genomic features impacting the largest number of genes.
| Genomic feature | Type | N | Most significant GO term | p-value (FDR) | Most significant SP-PIR keyword | p-value (FDR) |
|---|---|---|---|---|---|---|
| hsa.miR.768.5p | miRNA | 303 | GO:0005739 mitochondrion |
8.67E-09 (1.18E-05) |
acetylation | 1.10E-22 (1.40E-19) |
| hsa.miR.29a | miRNA | 154 | GO:0007049 cell cycle |
7.99E-20 (1.21E-16) |
cell cycle | 7.30E-17 (1.44E-13) |
| SPRY4 | methylation | 119 | GO:0003723 RNA binding |
3.19E-4 (0.4197) |
acetylation | 1.09E-6 (0.0013) |
| 16p13.3 | CNA | 117 | GO:0031974 membrane-enclosed lumen |
4.10E-5 (0.0506) |
iron-sulfur | 9.98E-5 (0.1257) |
| 12q23.1 | CNA | 113 | GO:0070013 intracellular organelle lumen |
4.29E-5 (0.0534) |
acetylation | 2.62E-6 (0.0032) |
| 1q42.3 | CNA | 113 | GO:0012505 endomembrane system |
7.3E-4 (0.8908) |
phosphoprotein | 4.71E-6 (0.0059) |
| 6p21.1 | CNA | 109 | GO:0042974 retinoic acid receptor binding |
4.86E-8 (6.38E-5) |
nucleus | 1.84E-5 (0.0228) |
| 17q25.3 | CNA | 108 | non-membrane-bounded organelle |
0.0092 (11.23) |
acetylation | 6.39E-9 (8.03E-6) |
| 1p36.11 | CNA | 103 | GO:0016071 mRNA metabolic process |
0.0046 (6.86) |
phosphoprotein | 1.31E-4 (0.1632) |
| 19p13.12 | CNA | 102 | GO:0043232 intracellular non-membrane-bounded organelle |
1.24E-5 (0.0150) |
nucleus | 1.24E-5 (0.0149) |
The most significantly enriched GO terms and SP-PIR keywords for the set of associated genes are listed together.