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The effect of treatment on World Health Organization (WHO) functional class. The percentage of patients in whom an improvement by ≥1 WHO functional class is reported at week 4, 8, and 12 for the placebo (n = 111), spironolactone (n = 21), ambrisentan (10 mg/day, n = 57), and ambrisentan + spironolactone (n = 10) treatment groups.
