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. 2013 Oct 21;16(2):269–279. doi: 10.1111/cmi.12218

Figure 5.

Figure 5

H2O2 output by infected macrophages regulates HIF-1α levels.A. Bw720c treatment reduces HIF-1α levels, but does not inhibit the host cell HIF-1α response when H-V macrophages are stressed by aminotriazole (AT) treatment.B. Lowering H2O2 levels by NAC treatment also reduces HIF-1a expression in both H-V and H-A macrophages.C. NAC treatment of H-V reduces the expression of hif-1α and 4 different hif-1α-target genes.D. Similarly, NAC treatment of H-A reduces the expression of hif-1α and 4 different hif-1α-target genes. *Student’s t-test, highest P-value = 0.013 < 0.05.