Table II.
Toxicity Type | Treatment Arm | |||||
---|---|---|---|---|---|---|
ABVD (n=24) | Stanford V (n=21) | |||||
Grade | Grade | |||||
3 | 4 | 5 | 3 | 4 | 5 | |
(%) | (%) | (%) | (%) | (%) | (%) | |
Haemoglobin | 13 | 4 | - | 33 | - | - |
Leucocytes | 50 | 17 | - | 24 | 48 | - |
Lymphopenia | 71 | - | - | 86 | - | - |
Neutrophils | 8 | 79 | - | 29 | 48 | - |
Platelets | 8 | - | - | 5 | - | - |
Transfusion (PRBCs) | 4 | - | - | 10 | - | - |
Hypertension | 4 | - | - | - | - | - |
Cardiac-other | 4 | - | - | - | - | - |
Fatigue | 17 | - | - | - | - | - |
Fever | - | - | - | 5 | - | - |
Constipation | 4 | - | - | - | 5 | - |
Dehydration | 8 | - | - | - | - | - |
Dysphagia-esophageal (radiation) | - | - | - | 5 | - | - |
Nausea | 4 | - | - | 5 | - | - |
Stomatitis | 4 | - | - | - | - | - |
Vomiting | 8 | - | - | - | - | - |
Alkaline phosphatase | 8 | - | - | - | - | - |
Hypoalbuminemia | 4 | - | - | - | - | - |
Infection with grade 3 or 4 neutropenia | 4 | 4 | - | 10 | - | 5 |
Gastrointestinal haemorrhage | - | - | - | - | - | 5 |
Hyperglycaemia | 8 | - | - | 10 | - | - |
Muscle weakness | - | - | - | 10 | - | - |
Neuropathy-motor | - | 8 | - | 14 | - | - |
Neuropathy-sensory | 4 | 8 | - | - | - | - |
Syncope | 4 | - | - | - | - | - |
Abdominal pain | - | - | - | 5 | - | - |
Arthralgia | 4 | - | - | - | - | - |
Chest pain | 4 | - | - | - | - | - |
Myalgia | 8 | - | - | - | 5 | - |
Deep vein thrombosis | 4 | - | - | - | - | - |
Pain-other | 4 | - | - | 5 | - | - |
DLCO decrease | 4 | - | - | - | - | - |
Dyspnea | 4 | 13 | - | - | - | - |
Hypoxia | 4 | 4 | - | - | - | - |
Pneumonitis/pulmonary infiltrates | 8 | - | - | - | - | - |
Pulmonary-other | - | - | 8 | - | - | - |
WORST DEGREE | 13 | 79 | 8 | 33 | 57 | 10 |
Abbreviations: HL, Hodgkin lymphoma; PRBC, packed red blood cells; DLCO, diffusion capacity of the lung for carbon monoxide.