Table II.
Adverse event data for older HL patients.
| Toxicity Type | Treatment Arm | |||||
|---|---|---|---|---|---|---|
| ABVD (n=24) | Stanford V (n=21) | |||||
| Grade | Grade | |||||
| 3 | 4 | 5 | 3 | 4 | 5 | |
| (%) | (%) | (%) | (%) | (%) | (%) | |
| Haemoglobin | 13 | 4 | - | 33 | - | - |
| Leucocytes | 50 | 17 | - | 24 | 48 | - |
| Lymphopenia | 71 | - | - | 86 | - | - |
| Neutrophils | 8 | 79 | - | 29 | 48 | - |
| Platelets | 8 | - | - | 5 | - | - |
| Transfusion (PRBCs) | 4 | - | - | 10 | - | - |
| Hypertension | 4 | - | - | - | - | - |
| Cardiac-other | 4 | - | - | - | - | - |
| Fatigue | 17 | - | - | - | - | - |
| Fever | - | - | - | 5 | - | - |
| Constipation | 4 | - | - | - | 5 | - |
| Dehydration | 8 | - | - | - | - | - |
| Dysphagia-esophageal (radiation) | - | - | - | 5 | - | - |
| Nausea | 4 | - | - | 5 | - | - |
| Stomatitis | 4 | - | - | - | - | - |
| Vomiting | 8 | - | - | - | - | - |
| Alkaline phosphatase | 8 | - | - | - | - | - |
| Hypoalbuminemia | 4 | - | - | - | - | - |
| Infection with grade 3 or 4 neutropenia | 4 | 4 | - | 10 | - | 5 |
| Gastrointestinal haemorrhage | - | - | - | - | - | 5 |
| Hyperglycaemia | 8 | - | - | 10 | - | - |
| Muscle weakness | - | - | - | 10 | - | - |
| Neuropathy-motor | - | 8 | - | 14 | - | - |
| Neuropathy-sensory | 4 | 8 | - | - | - | - |
| Syncope | 4 | - | - | - | - | - |
| Abdominal pain | - | - | - | 5 | - | - |
| Arthralgia | 4 | - | - | - | - | - |
| Chest pain | 4 | - | - | - | - | - |
| Myalgia | 8 | - | - | - | 5 | - |
| Deep vein thrombosis | 4 | - | - | - | - | - |
| Pain-other | 4 | - | - | 5 | - | - |
| DLCO decrease | 4 | - | - | - | - | - |
| Dyspnea | 4 | 13 | - | - | - | - |
| Hypoxia | 4 | 4 | - | - | - | - |
| Pneumonitis/pulmonary infiltrates | 8 | - | - | - | - | - |
| Pulmonary-other | - | - | 8 | - | - | - |
| WORST DEGREE | 13 | 79 | 8 | 33 | 57 | 10 |
Abbreviations: HL, Hodgkin lymphoma; PRBC, packed red blood cells; DLCO, diffusion capacity of the lung for carbon monoxide.