Table 1.
Subpopulations of T cells in the CNS of CpG- and buffer-treated neutropenic mice 42 h after infection
| |
Absolute no. of cells
a
|
Percent among all CD45
+
cells
a
|
||
|---|---|---|---|---|
| CpG | Buffer | CpG | Buffer | |
| CD45+ cells |
237427 (122770/257348) |
228016 (169274/314119) |
|
|
| T cells (CD45+CD3+) |
4274 (3560/4607) |
4844 (3065/8602) |
2 (1.8/2.9)b |
3.2 (2.8/3.6) |
| Regulatory T cells CD45+CD4+CD3+CD25+FoxP3+ |
172 (122/307) |
375 (167/489) |
0.08 (0.06/0.13)b |
0.2 (0.12/0.55) |
| NK cells CD45+NK1.1+CD3- |
3631 (3138/7180) |
2588 (1882/6996) |
2.6 (1.6/3) |
2.2 (1.5/3.6) |
| Inflammatory monocytes CD45+CD11b+Ly6ChighCCR2+ |
66905 (46994/101306) |
40683 (23199/55803) |
39.4 (27.6/46.9)b |
25.9 (23.3/28.9) |
| Monocytes CD45+CD11b+Ly6ChighCCR2- |
13798 (6089/22579) |
13150 (7054/24206) |
7 (4.9/11) |
8.54 (5/11.7) |
| Monocytes CD45+CD11b+Ly6CintCCR2- |
40918 (15076/69499) |
39167 (19894/65079) |
22 (15.9/27.51) |
26.4 (17.35/34) |
| Microglia CD45intCD11bintLy6C- | 6392 (4150/27330) | 5316 (2869/18381) | 3.56 (2.6/10.62) | 4.69 (2.48/7.71) |
aData are medians (25th/75th percentiles) determined by forward and side-scatter properties from the right hemisphere of animals (n = 6-7/group) of at least three separate experiments.
bSignificantly different (P <0.05) vs. buffer-treated group (Mann-Whitney U test).