Table 1.
Antimicrobial activities of the undecapeptides generated in this study
| Minimal inhibitory | omiganan | GA-W2 | GA-W3 | GA-W4 | GA-K3 | GA-K4 | GA-K4L | GA-K4A | GA-K4AL |
|---|---|---|---|---|---|---|---|---|---|
| concentration (μg/ml) | (MBI-226) | (#0.0)a | (#1.0) | (#1.1) | (#2.0) | (#2.1) | (#2.11) | (#2.12) | (#2.13) |
| Gram-positive bacteria | |||||||||
| B. subtilis | 6.3 | 25 | 6.3 | 3.1 | 6.3 | 3.1 | 6.3 | 25 | 6.3 |
| M. luteus | 6.3 | 12.5 | 3.1 | 3.1 | 3.1 | 3.1 | 3.1 | 25 | 6.3 |
| S. aureus | 6.3 | 25 | 6.3 | 6.3 | 12.5 | 6.3 | 12.5 | 100 | 6.3 |
| S. epidermis | 12.5 | 50 | 6.3 | 3.1 | 6.3 | 6.3 | 12.5 | 100 | 6.3 |
| Gram-negative bacteria | |||||||||
| E. coli | 25 | 50 | 25 | > 200 | 12.5 | 12.5 | 50 | 100 | 12.5 |
| S. dysentariae | 50 | 25 | 12.5 | 200 | 25 | 25 | 25 | 50 | 12.5 |
| S. typhimorium | 100 | 200 | 100 | > 200 | 50 | 50 | 200 | 200 | 25 |
| K. pneumoniae | 50 | 50 | 12.5 | 200 | 12.5 | 12.5 | 50 | 200 | 6.3 |
| P. aeruginosa | 200 | 200 | > 200 | > 200 | 25 | 12.5 | 25 | 200 | 12.5 |
| GM (geometric mean of MICs) | |||||||||
| Gram (+)b | 7.5 | 25.0 | 5.3 | 3.7 | 6.3 | 4.4 | 7.4 | 50.0 | 6.3 |
| Gram (-)c | 66.0 | 75.8 | ≥ 43.5 | ≥ 303.1 | 21.8 | 18.9 | 50.0 | 132.0 | 12.5 |
| Gram (+,-)d | 25.1 | 46.3 | ≥ 17.0 | ≥ 42.8 | 12.5 | 9.9 | 21.4 | 85.7 | 9.2 |
aAmino acid sequences are represented by the corresponding model numbers (refer to Fig. 1)
bagainst 4 Gram-positive strains tested
cagainst 5 Gram-negative strains tested
dagainst all of the 9 strains tested