Table 3.

Genes which are >3-fold down regulated in TNFα (± FSH)-treated granulosa cells compared with control (± FSH) cells

Gene symbol	Fold change	Gene symbol	Fold change	Gene symbol	Fold change
	(TNFα vs non TNFα treated)		(TNFα vs non TNFα treated)		(TNFα vs non TNFα treated)
Apoptosis
TRIB2	5.7
Cell morphology
DACT1	4.1	ACTG2	3.3	MYO1B	3.1
Cytokines, hormones and receptors
ROBO2	7.9	HEG1	5	PTN	3.5
EFNA5	7.3	PLXNC1	4.4	AMH	3.4
FST	6.2	PPARG	4.2	NR5A2	3.1
INHA	5.8	ANGPT2	3.8	KIT	3
INHBA	5.8	CD36	3.6
NMB	5.5	EPHA7	3.6
Extracellular matrix and synthesis
SPOCK2	5.0	FBLN5	4.8	EFEMP1	3.3
SRGN	5.5
Intercellular and cell to matrix adhesion
CYR61	5	CAV1	4.1	CTNNAL1	3.3
TSPAN5	4.9	TNFAIP6	3.5	CLDND1	3.3
NPNT	4.6	SMOC2	3.4
Ion transport
KCNN2	3.6	ATP4B	3.1
Proteolysis and inhibition
TLL2	4.8	PRSS35	3.4	SERPINE2	3.0
Transcription regulation
TOX	4.1
Transport
MAL2	4.0	SLC2A3	3.7	NPC1	3.0
Other enzymes
CHST8	8.4	DDAH1	4.4	PLA2G7	3.5
VNN1	6.4	HPSE	4.1	GCLC	3.4
STC1	5.8	MVK	3.7	TRIM2	3.2
PPAP2B	5.5	PDK4	3.6
HSD17B1	4.8	GYLTL1B	3.6
PTGS2	4.6
Other signalling
TPD52L1	7.3	DAB2	3.4	CCND2	3.1
RGS2	4.6	FGD5	3.2	SMAD2	3.1
SORBS2	4.4	RASL11B	3.2
RGMB	3.8	NTS	3.2
Other
ZNF608	4.6	EEPD1	4.4	CAPRIN2	3.5
SUSD4	4.5	LINGO2	3.7	LGALS3	3.1

The level of fold change and statistical significance ( ≥ 3-fold, P < 0.05) was determined by one-way ANOVA with post-hoc Benjamini-Hochberg testing for multiple corrections. The association of genes with functional terms in this table was determined manually for each gene based on information obtained through the Entrez Gene database of NCBI. Genes are listed in descending order of fold change in each category.