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. 2013 Dec 5;10:146. doi: 10.1186/1742-2094-10-146

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Copyright © 2013 Bachstetter et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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PLP-ISEdel mice have a progressive astrogliosis throughout the brain. (A) Strong increase in glial fibrillary acidic protein (GFAP) staining is seen in the PLP-ISEdel mice. (B) Quantification of the GFAP staining in the outlined regions is shown as a heat map, with the average of the signal of the 2-month-old wild-type (WT) mice for each brain region used as 100%. Mean ± SEM for each brain region is indicated. (n = 5 to 6 per group). Abbreviations: hippocampus (hip); Cpu, striatum (caudate putamen).