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. 2013 Dec 5;10:146. doi: 10.1186/1742-2094-10-146

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Copyright © 2013 Bachstetter et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Amyloid precursor protein (APP) accumulation is seen in the 4-month-old PLP-ISEdel mice. (A) In 4-month-old wild-type (WT) mice, APP staining was localized to the neuronal cell body and no APP⁺ spheroids were found. In 4-month-old PLP-ISEdel mice, many APP⁺ spheroids were seen in the thalamus. The black box shows the region of the higher power image on the right. (B) In the striatum, APP accumulation was seen in the white matter tracks in the 4-month-old PLP-ISEdel mice but not in the WT mice. Arrow indicates the APP⁺ spheroid shown in the higher power image on the right.