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Adverse events reported at ≥4% frequency from baseline to 1 year
| Adverse event | Upfront (N = 267) | Delayed ( = 274) | P value |
|---|---|---|---|
| Fever | 18 (6%) | 1 (0%) | 0.0001 |
| Creatinine | 10 (4%) | 3 (1%) | 0.045 |
| Limb edema | 4 (1%) | 0 (0%) | 0.042 |
| Fatigue | 15 (5%) | 6 (2%) | 0.038 |
| Nausea | 29 (11%) | 17 (6%) | 0.048 |
| Vomiting | 10 (4%) | 6 (2%) | 0.29 |
| Hot flashes | 21 (8%) | 27 (10%) | 0.42 |
| Myalgia | 17 (7%) | 14 (5%) | 0.53 |
| Arthralgia | 34 (13%) | 31 (11%) | 0.59 |
| Back pain | 66 (25%) | 64 (23%) | 0.67 |
