Figure 3. Median overall survival (OS) from diagnosis of CLL for patients who ultimately acquire “double hit” is poor (7.1 years).
Patients who ultimately acquire both 17p and 11q deletions (“double hit”) have a poor prognosis from time of diagnosis of CLL with a median OS of 7.1 years. When median survival for these patients is considered from the time-point of sentinel FISH event (when 17p- and 11q- are acquired), their prognosis is very poor (median OS 1.9 years). See Figure 2.