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. 2013 Dec 29;11(1):20. doi: 10.1186/1897-4287-11-20

Figure 3.

Figure 3

Kaplan-Meier estimated by location of APC mutation. A) Using CRC as end-point of analysis: The graph shows the effect the location of the APC mutation has on age of diagnosis of CRC in Dutch FAP patients. A significant difference is observed between the attenuated (APC AFAP), intermediate (APC, 53 years) and severe (MCR, 40 years) polyposis phenotype; Log-rank p ≤ 0.0001. B) Using adenomas as end-point of analysis: The graph shows the effect the location of the APC mutation has on age of diagnosis of adenomas in Dutch FAP patients. A significant difference is observed between the attenuated (APC AFAP, 35 years), intermediate (APC, 24 years) and severe (MCR, 15 years) polyposis phenotype; Log-rank p ≤ 0.0001.