Fig. 3.
RNA interference by three anti-LAT1 siRNA sequences reduce 3H-l-DOPA uptake in GBM. Robust protein knockdown (a) was achieved in T98 cells transfected with anti-LAT1 siRNA compared with NT siRNA at 72 h. Reduction in LAT1 expression correlates with lower 3H-l-DOPA uptake (b). Data shown represents three independent experiments. Data are plotted as the mean ± SE of the mean of independent experiments with results normalized to NT siRNA vector transfected cells (* P < 0.05; † P < 0.01)