Figure 4.

Analysis of simulated trajectories in the inferred maps. Unless otherwise mentioned, the results correspond to the constructs β^WT-TM (black), β^S403D-TM (blue), and β⁻-TM (red). (a) Ensemble-averaged propagator Π(d, t), defined as the probability density function to move by a given distance in t = 10 s. (b) Propagator Π(d, t) for the construct β^WT-TM computed at different times t. (Plain lines) Adjustments with the Gaussian curves exp(−d²/2χ²(t))/2πχ²(t). (c) Curves χ(t). (Inset) Propagators for the construct β^WT-TM as a function of the rescaled variable ρ = d/χ(t). (d) Mean-squared displacement as a function of time. (Straight lines) Subdiffusive behavior at short timescales. (e) Time-course of the number of receptors at a single synapse. (Inset) Distribution of the minimum (in red) and maximum (in blue) number of receptors computed over traces of 300 s for all the gephyrin clusters. (f) Autocorrelation functions (in gray) for the time traces of number of receptors at gephyrin clusters (computed over 300 s). (Red line) Average autocorrelation function. To see this figure in color, go online.