Figure 5.

Physical parameters of epithelization. (A and B) Closure time t_c (solid circles) as a function of the initial effective radius, R₀, fitted by Eq. 1 (solid curves) with the constraints D,R_max ≥ 0. Each circle corresponds to one wound. (A) MDCK wounds. Wild-type (D = 353 ± 38 μm² h⁻¹, R_max = 117 ± 11 μm, $N=130$), Rho⁻ assay (D = 278 ± 40 μm² h⁻¹, R_max = 114 ± 9 μm, N = 30), and Rac⁻ assay (σ_p/ξ = 198 ± 22 μm² h⁻¹, R_max = 105 ± 11 μm, N = 34). (B) HEK-HT assay (σ_p/ξ = 572 ± 57 μm² h⁻¹,R_max = 132 ± 12 μm, N = 653) and HEK-RasV12 assay (σ_p/ξ = 1531 ± 363 μm² h⁻¹, R_max = 223 ± 77 μm, N = 65). (C–F) Epithelization coefficient, D, and cutoff radius, R_max, for MDCK (C and D) and HEK wounds (E and F). Error bars correspond to a 95% confidence level.