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. Author manuscript; available in PMC: 2014 Oct 21.

Published in final edited form as: Chem Res Toxicol. 2013 Sep 12;26(10):1486–1497. doi: 10.1021/tx400213m

Table 3.

Effect of occupational BD exposure on of N7-THBG concentrations in human leukocyte DNA

Controls				BD Exposed

Sample	BD Exposure (ppm)	Amt. of DNA analyzed (μg)^a	Adducts/ 10⁹ nucleotides	Sample	BD Exposure (ppm)	Amt. of DNA analyzed (μg)^a	Adducts/ 10⁹ nucleotides
1	0.005	91.7	1.02^*	11	2.2	83.3	6.55
2	0.003	94.6	0.55^*	12	3.1	103.9	9.93
3	0.004	94.8	6.64	13	1.2	86.6	6.65
4	0.005	98.7	1.56^*	14	3.3	69.1	7.29
5	0.006	81.9	3.81	15	2.1	71.3	10.11
6	0.040	76.84	2.64^*	16	0.92	82.98	8.68
7	0.005	78.80	5.97	17	0.21	76.84	15.7
8	0.007	45.94	3.07	18	0.24	78.80	4.37
9	0.010	84.65	4.61	19	0.99	45.94	12.8
10	0.007	75.84	0.90^*	20	0.83	84.65	15.1
Mean ± SD	0.009 ± 0.01	82.4 ± 15.2	3.08 ± 2.15	Mean ± SD	1.51 ± 1.11	78.3 ± 14.9	9.72 ± 3.79

^*

Adduct amounts less than LOQ but greater than LOD.

^a

One third of total DNA amount was injected on column for HPLC-accurate mass MS/MS analysis.