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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Genet. 2013 Dec 22;46(2):176–181. doi: 10.1038/ng.2856

Figure 1. Clinical timelines and somatic mutation profiles for the discovery cases.

Figure 1

(a) Biopsy information with disease event timelines for the 10 WGS and WES cases. (b) Distribution of base substitution patterns of all somatic single nucleotide variants (SNVs) identified in the 6 paired FL-tFL genomes. The somatic SNVs for each case were sorted into three categories: shared (variants present in both FL and tFL samples), FL-specific and tFL-specific. Aberrant somatic hypermutation (aSHM) did not contribute to the majority of variants detected, with the exception of previously described gene targets (Supplementary Table 13).