Table 1. Quantitative phenotypes used to constrain and challenge the model.

	Name	Treatment	Marker	Value	Ref.
non-APA phenotypes	basal	-	cAMP	60 nM	[23], [121]
			STEPact	80%	[12]
			D32p34	0.2–0.5 uM	[122]
			D32p75	13 uM	[123]
	DAsliceD32	Striatal slices+DA≥10 uM Sampled at 5′.	D32p34	12 X basal	[6], [124]
			D32p75	0.5 X basal
	NMDAsliceD32	Striatal slices+NMDA 100 uM Sampled at 10′.	D32p34	0.5 X basal	[40], [125]
			D32p75	0.5 X basal
	activateRAS	1″ Ca2+ spikes in cult. hipp. cells.	RAS•RAF complex	Hill. h = 4.1 K = 0.8 uM	[49]
	sensitizedNMDAR	NMDA ± SKF38393 3 uM in cult. MSNs. Sampled at 10′	ERKpp	Qualitative	[19]
	trafficNMDAR	PFC slices+DA. t series.	NMDAR currents	Monoexpon.k = 0.15 min−1	[61]
		Striatal slices+EtOH. t series.			[60]
APA-phenotypes	APAib	APA to WT mice. IB. t series	ERKpp	Fig. 4D	[12]
			GluR1p	Fig. 4F	[12], [13]
	haploD1R	APA to Drd1a+/− mice. Sampled at 15′.	ERKpp	0.5 X WT	[19]
			GluR1p	1 X WT
	haploGolf	APA to GnaI+/− mice. Sampled at 15′.	ERKpp	0.9 X WT	[20]
			GluR1p	0.6 X WT
	D32KO	APA to D32KO mice. Sampled at 15′.	ERKpp	0.4 X WT	[12]
			GluR1p	0.35 X WT	[13]

STEPact, non-phosphorylated STEP over total STEP; D32p34, DARPP32 phosphorylated in threonine 34; D32p75, DARPP32 phosphorylated in threonine 75; PFC, prefrontal cortex; APA, acute psychostimulant administration; WT, wild type; IB, immunoblot; ERKpp, active ERK; GluR1p, AMPAR subunit GluR1 phosphorylated in the PKA site; t. series, time series; Monoexp, monoexponential. The names of the phenotypic variables are built from the name and marker columns except for parameterized time series or dose responses where it is used the parameter name instead of the marker.