Table 1. Functional transcriptomic/proteomic tick and TBP interaction studies.

Tick species	Tick organs	Tick-borne pathogens	Technique used	Number of differentially expressed transcripts/proteins	Refs
Transcriptomic studies
D. variabilis female	SG, MG, OV	R. montanensis	DD-PCR	54	[11]
I. scapularis nymph	SG	B. burgdorferi	LCS	10	[14]
I. scapularis nymph	WT	Langat virus	MH	48	[17]
I. scapularis embryos	IDE8 tick cells	A. marginale	SSH	35	[15]
I. ricinus female	WT	B. burgdorferi	SH	11	[13]
R. appendiculatus female	SG	T. parva	LCS	3	[12]
R. microplus male	SG	A. marginale	SSH	99	[16]
Proteomic studies
I. scapularis embryos	IDE8 tick cells	A. marginale	2D-DIGE, MALDI-TOF MS	3	[15]
I. scapularis embryos	ISE6 tick cells	A. phagocytophilum	IEF, 2D-DIGE, MALDI-TOF MS, RP-LC MS/MS	5	[20]
R. bursa female	WIO	T. annulata	2D-DIGE, RP-LC MS/MS, MALDI-TOF MS	16	[21]
R. microplus female	OV	B. bovis	IEF, 1/2DGE, HPLC-ESI-MS/MS	19	[18]
R. microplus female	MG	B. bovis	IEF, 1/2DGE, HPLC-ESI-MS/MS	20	[19]
R. sanguineus female	WIO	Ric. conorii	2D-DIGE, RP-LC MS/MS, MALDI-TOF MS	10	[21]
R. sanguineus female	WIO	E. canis	2D-DIGE, RP-LC MS/MS, MALDI-TOF MS	6	[21]
R. turanicus female	WT	A. ovis	IEF, 2D-DIGE, MALDI-TOF MS, RP-LC MS/MS	50	[20]
R. turanicus female	WIO	A. ovis	2D-DIGE, RP-LC MS/MS, MALDI-TOF MS	9	[21]

SG: salivary glands, MG: midgut, OV: ovaries, WT: whole ticks, WIO: whole internal organs; DD-PCR: differential-display polymerase chain reaction, LCS: cDNA library clones sequencing, MH: microarray hybridization, SH: subtractive hybridization, SSH: suppression-subtractive hybridization; D: dimensional, DIGE: differential in-gel electrophoresis, DGE: dimensional gel electrophoresis, ESI: tandem electrospray, HPLC: high-performance liquid chromatography, IEF: isoelectric focusing, MALDI-TOF: matrix-assisted laser desorption/ionization time-of-flight, MS: mass spectrometry, RPLC: reversed phase liquid chromatography.