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. 2014 Jan 30;10(1):e1004134. doi: 10.1371/journal.pgen.1004134

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© 2014 Kurki et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The Finnish discovery and replication cohorts represent a population with over two-fold increased risk of subarachnoid hemorrhage from ruptured saccular intracranial aneurysm (sIA-SAH). The Finnish discovery cohort was intentionally enriched with familial sIA patients, and 9.4M genotyped and imputed variants were studied. The loci with p<5E-6 were replicated in an independent and unselected Finnish sIA sample. The allele frequencies and effect sizes of the replicated variants in Finland were finally compared to continental European population using a Dutch sample. The sIA-SAH risk is not increased in the Netherlands (‘general risk’ in the figure).