Table 2. Five loci with a genome-wide significant association to saccular intracranial aneurysm (sIA) disease in the Finnish and Dutch samples.

Case vs. control analysis		Finnish discovery				Finnish replication				Finnish meta-analysis				Dutch replication				All meta-analysis
SNP*	Gene	Case MAF	Ctrl MAF	OR	P	Case MAF	Ctrl MAF	OR	P	Case MAF	Ctrl MAF	OR	P	Case MAF	Ctrl MAF	OR	P	OR§	P
rs74972714 (C/A) 2q23.3 (150370860 bp)	LYPD6 (40 kb)**	0.034	0.017	2.73	3.43E-06	0.049	0.028	1.88	4.11E-06	0.0421	0.0235	2.10	7.41E-11	0.017	0.016	1.04	4.37E-01	1.89	1.42E-09
rs113816216 (G/C) 5q31.1 (132846228 bp)	FSTL4***	0.045	0.021	2.31	8.26E-07	0.032	0.021	1.60	2.57E-03	0.0382	0.0209	1.92	1.74E-08	0.045	0.039	1.30	4.53E-02	1.66	3.17E-08
rs75018213 (A/G) 6q24.2 (146052178 bp)	EPM2A***	0.051	0.027	2.11	3.44E-06	0.042	0.024	1.85	2.85E-05	0.0461	0.0253	1.97	2.25E-10	0.029	0.023	1.50	3.39E-02	1.87	7.14E-11
rs1333042 (G/A)† 9p21.3(22103813 bp)	CDKN2B-AS1	0.500	0.432	1.32	3.01E-06	0.481	0.417	1.30	6.30E-07	0.490	0.423	1.31	1.81E-11	0.543	0.479	1.32	3.42E-06	1.31	6.71E-16
rs919433 (A/G)‡ 2q33.1(198166565 bp)	ANKRD44***	0.480	0.428	1.25	2.53E-04	0.486	0.446	1.18	1.01E-03	0.483	0.440	1.21	2.15E-06	0.418	0.332	1.43	9.77E-09	1.27	2.20E-12
rs12472355 (A/C)‡ 2q33.1(198205840 bp)	ANKRD44 (30 kb)**	0.478	0.427	1.24	2.89E-04	0.488	0.443	1.21	2.23E-04	0.483	0.437	1.23	4.84E-07	0.391	0.310	1.39	1.05E-07	1.27	1.87E-12

^*For each variant minor allele/major allele, locus and base pair position are given.

^**The variant's distance (kb) to the nearest gene is given.

^***Located in the intron of the given gene.

^†The previously reported 9p21.3 locus [12], [39].

^‡The previously studied 2q33.3 locus with inconclusive evidence (see Materials and Methods).

^§Some heterogeneity in effect sizes exists between cohorts. See Table S9 for heterogeneity statistics.