Table 3. Comparison of clinical, laboratory manifestations and complications in the AKI and non-AKI groups in the confirmed scrub typhus study population (scrub typhus PCR positive, no. of patients: 49).
| Parameter | AKI (n = 26) | No AKI (n = 23) | P value (two tailed) |
| Symptoms | |||
| Fever | 26 | 22 | 0.283 |
| Shortness of breath | 20 | 13 | 0.129 |
| Jaundice | 16 | 5 | 0.005 |
| Pain abdomen | 6 | 9 | 0.224 |
| Vomiting | 7 | 8 | 0.551 |
| Oliguria | 13 | 0 | <0.001 |
| Headache | 7 | 7 | 0.786 |
| Altered sensorium | 8 | 4 | 0.277 |
| Bleeding manifestations | 5 | 5 | 0.828 |
| Loose motions | 2 | 3 | 0.537 |
| Bodyaches | 3 | 0 | 0.093 |
| Seizures | 1 | 1 | 0.929 |
| Signs | |||
| Tachycardia | 20 | 16 | 0.560 |
| Hepatomegaly | 18 | 16 | 0.980 |
| Tachypnea | 18 | 15 | 0.765 |
| Splenomegaly | 13 | 7 | 0.164 |
| Lymphadenopathy | 4 | 6 | 0.354 |
| Eschar | 5 | 4 | 0.868 |
| Rash | 1 | 1 | 0.929 |
| Others | |||
| Shock | 6 | 2 | 0.174 |
| ARDS | 17 | 11 | 0.215 |
| Mortality | 8 | 0 | 0.004 |
| Investigations | |||
| Hemoglobin (g/dL) | 10.7±2.8 | 9.7±2.2 | 0.174 |
| TLC (per µL) | 11923±6750 | 11363±6426 | 0.771 |
| Platelet count (per µL) | 82560±75525 | 87476±68821 | 0.820 |
| Serum total bilirubin (mg/dL) | 7.6±9.7 | 1.8±2.9 | 0.013 |
| SGOT (U/L) | 587±1742 | 124±96 | 0.255 |
| SGPT (U/L) | 226±538 | 75±45 | 0.243 |
| SAP (U/L) | 336±318 | 217±158 | 0.152 |
| Total protein (g/dL) | 6.2±1.2 | 6.2±1.0 | 0.848 |
| Serum albumin (g/dL) | 2.8±0.6 | 3.1±0.8 | 0.387 |
| Blood urea (mg/dL) | 137±68 | 44±29 | <0.000 |
| Serum creatinine (mg/dL) | 2.8±1.5 | 0.8±0.2 | <0.000 |
| Scrub typhus IgM ELISA positivity | 25 | 14 | 0.002 |
| Complication | |||
| Severe anemia | 8 | 7 | 0.980 |
| Leukocytosis | 10 | 8 | 0.881 |
| Leukopenia | 0 | 1 | 0.272 |
| Thrombocytopenia | 17 | 15 | 0.801 |
| Hypoalbuminemia | 18 | 15 | 0.817 |
| Hyperbilirubinemia | 19 | 7 | 0.002 |
| Elevated SGOT | 20 | 15 | 0.488 |
| Elevated SGPT | 18 | 11 | 0.231 |
| Elevated SAP | 14 | 11 | 0.431 |
AKI: acute kidney injury, ARDS: acute respiratory distress syndrome, ELISA: enzyme linked immunosorbent assay, IgM: immunoglobulin M, PCR: polymerase chain reaction, SAP: serum alkaline phosphatase SGOT: serum glutamate oxaloacetate aminotransferase, SGPT: serum glutamate pyruvate aminotransferase, TLC: total leukocyte count.