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. 2014 Jan 30;10(1):e1003890. doi: 10.1371/journal.ppat.1003890

Figure 2. Administration of r-hIL-7 leads to increases in gut mucosal T-cells.

Figure 2

The proportion of CD4+ (A) and CD8+ (C) T-cells in gut tissue was assessed after gating in CD3+ cells at baseline (prior to r-hIL-7) and at week 12 showing an increase in the proportion of CD4+ T cells (P = 0.042) and a decrease in the proportion of CD8+ T-cells (P = 0.042). Comparisons of HIV+ participants with HIV− controls were done by Mann-Whitney testing. The number of CD4+ (B) and CD8+ (D) T-cells per gram of gut tissue was also calculated as described in methods and showed increases in the numbers of CD4+ and CD8+ T-cells (P = 0.019 and P = 0.002 respectively) as well as normalization of CD4+ T-cell numbers compared to HIV− controls' numbers at week 12 (P = 0.022 at baseline and P = 0.746 at week 12 by Mann-Whitney test). Baseline indicates prior to any drug administration, gut biopsies were performed between 1 and 3 weeks prior to the first r-hIL-7 injection at day 0 (D0).