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. 2014 Jan 30;10(1):e1003890. doi: 10.1371/journal.ppat.1003890

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Plasma levels of sCD14 (A) and D-dimer (B) decreased significantly at week 12 after r-hIL-7 compared to baseline (D0) after a transient and not statistically significant increase at day 21 or 28 after the first injection. Day 0 was the day of the first r-hIL-7 injection. Significant associations were seen between the changes in plasma sCD14 and the changes in CD4⁺ T-cells in colonic mucosa as measured by flow cytometry (C) and with the CD3⁺ changes observed by IHC (D).