Figure 3. The HPLC surveyed the dopamine turnover rate in the injured animals.

(A) The turnover rate of dopamine in the 2-Pa group showed no significant changes (except at 24 hours after injury), but the rate decreased initially in the 6-Pa-injured group and then increased after 8 weeks (p<0.05*). (B) The dopamine turnover rate increased on the ipsilateral side of the nucleus accumbens (NAc) in the 2-Pa injured group and increased significantly at the chronic stage of injury (8 weeks later). The dopamine concentrations in the striatum (C) and the nucleus accumbens (Nac) (D) did not show significant changes after injury and a significant decrease in the Nac of the 2-Pa-injured group was only shown at 1 day post injury (D, unpaired t-test, p<0.05). (Note: *indicates p<0.05; **indicates p<0.01; and ***indicates p<0.001).