Figure 5.

A The HuH6 tumor xenografts (as described in Figure 4) were weighed at euthanasia. The mean tumor weights from animals treated with M002 alone or M002+ XRT were significantly smaller than weights of the tumors from animals treated with vehicle or vehicle+XRT. Bars represent mean. Tumor weights were not altered by the addition of XRT to either the vehicle or M002 treatments. B HuH6 tumor xenograft volumes were measured biweekly with calipers [(width)²×length]/2. Data reported as mean fold change in tumor volume ± standard error. In the HuH6 xenografts, there was a significant decrease in tumor growth that began at day 7 following treatment that continued to the end of the study. The addition of low dose XRT to either the vehicle or M002 treatments had no significant effect upon tumor growth.