Table 3. Characteristics of the Studies about the XRCC1 Arg280His polymorphism (rs25489) Included in the Meta-analysis.
Author | Year | Ethnicity | Cancer Site | Genotyping Method | Control Source | Matching Criteria | Adjusted Variables | Case | Control | HWEc | MAFd | ||||||
N | AA | AB | BB | N | AA | AB | BB | ||||||||||
Majumder | 2005 | Asian | Oral | PCR-RFLP | HBa | None | None | 310 | 228 | 79 | 3 | 348 | 264 | 81 | 3 | 0.232 | 0.125 |
Harth | 2008 | Caucasian | Head&neck | RT-PCR | HB | None | Age, sex | 312 | 283 | 28 | 1 | 300 | 270 | 30 | 0 | 0.362 | 0.050 |
Applebaum | 2009 | Mixed | Head&neck | PCR-RFLP | PBb | Age, sex | Age, sex, race, education, smoke, alcohol, HPV16 | 484 | 437 | 46 | 1 | 548 | 492 | 52 | 4 | 0.052 | 0.055 |
Majumder | 2007 | Asian | Oral | PCR-RFLP | HB | None | Age, sex, smoke | 307 | 225 | 79 | 3 | 387 | 297 | 87 | 3 | 0.213 | 0.120 |
Tae | 2004 | Asian | Head&neck | MAPA | HB | None | Age, smoke, alcohol | 135 | 113 | 21 | 1 | 168 | 139 | 29 | 0 | 0.221 | 0.086 |
Ramachandran | 2006 | Asian | Oral | PCR-RFLP | PB | Age, sex | Age, sex, smoke, alcohol, betel quid chewing | 110 | 77 | 31 | 2 | 110 | 83 | 26 | 1 | 0.502 | 0.127 |
Kumar | 2012 | Asian | Head&neck | PCR-RFLP | PB | Age, sex, habits | None | 278 | 129 | 123 | 26 | 278 | 142 | 116 | 20 | 0.575 | 0.281 |
Gugatschka | 2011 | Caucasian | Head&neck | TaqMan | PB | None | None | 168 | 159 | 9 | 0 | 463 | 430 | 32 | 1 | 0.621 | 0.037 |
Ho | 2007 | Mixed | Oral | PCR-RFLP | HB | None | Age, sex, ethnicity, family history, smoke, alcohol, radiation exposure | 138 | 125 | 13 | 0 | 503 | 453 | 50 | 0 | 0.241 | 0.050 |
HB: Hospital based;
PB: Population based;
HWE: Hardy-Weinberg equilibrium in controls;
MAF: Minor allele frequency in controls.