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. 2014 Jan 30;9(1):e86798. doi: 10.1371/journal.pone.0086798

Table 3. Characteristics of the Studies about the XRCC1 Arg280His polymorphism (rs25489) Included in the Meta-analysis.

Author Year Ethnicity Cancer Site Genotyping Method Control Source Matching Criteria Adjusted Variables Case Control HWEc MAFd
N AA AB BB N AA AB BB
Majumder 2005 Asian Oral PCR-RFLP HBa None None 310 228 79 3 348 264 81 3 0.232 0.125
Harth 2008 Caucasian Head&neck RT-PCR HB None Age, sex 312 283 28 1 300 270 30 0 0.362 0.050
Applebaum 2009 Mixed Head&neck PCR-RFLP PBb Age, sex Age, sex, race, education, smoke, alcohol, HPV16 484 437 46 1 548 492 52 4 0.052 0.055
Majumder 2007 Asian Oral PCR-RFLP HB None Age, sex, smoke 307 225 79 3 387 297 87 3 0.213 0.120
Tae 2004 Asian Head&neck MAPA HB None Age, smoke, alcohol 135 113 21 1 168 139 29 0 0.221 0.086
Ramachandran 2006 Asian Oral PCR-RFLP PB Age, sex Age, sex, smoke, alcohol, betel quid chewing 110 77 31 2 110 83 26 1 0.502 0.127
Kumar 2012 Asian Head&neck PCR-RFLP PB Age, sex, habits None 278 129 123 26 278 142 116 20 0.575 0.281
Gugatschka 2011 Caucasian Head&neck TaqMan PB None None 168 159 9 0 463 430 32 1 0.621 0.037
Ho 2007 Mixed Oral PCR-RFLP HB None Age, sex, ethnicity, family history, smoke, alcohol, radiation exposure 138 125 13 0 503 453 50 0 0.241 0.050
a

HB: Hospital based;

b

PB: Population based;

c

HWE: Hardy-Weinberg equilibrium in controls;

d

MAF: Minor allele frequency in controls.