Table 2. Clinical characteristics of four groups based on the results of free-running provocation and methacholine provocation tests.
MBPT (+) | MBPT (−) | |||
EIB (+) N = 43 | EIB (−) N = 7 | EIB (+) N = 27 | EIB (−) N = 30 | |
Age (mean, yr) | 21.7±0.6 | 20.6±0.6 | 24.1±1.5 | 23.6±1.1 |
Nonsmoker (None/total, %) | 21/30 (70) | 4/6 (66.7) | 10/16 (62.5) | 15/20 (75) |
History of asthma (%) | 24 (55.8) | 2 (28.6) | 9 (33.3) | 11 (36.7) |
Temperature (mean °C)* | 12.0±1.9 | 11.0±4.7 | 7.4±2.2 | 17.8±2.1 |
Humidity (mean %)* | 45.7±2.2 | 47.4±8.9 | 45.4±2.4 | 52.3±2.2 |
Atopy rate (%) | 93.5 | 100 | 77.8 | 72 |
Serum IgE (mean, IU/mL) | 759.7±149.3 | 185.3±50.5 | 233.4±53.8 | 375.1±151.5 |
Sinusitis (%) | 29.6 | 0 | 35.3 | 15.8 |
Sputum analysis | ||||
Macrophage (mean, %) | 76.5±3.7 | 68.5±8.2 | 69.1±9.3 | 79.6±3.7 |
Neutrophil (mean, %) | 13.7±3.5 | 18.7±4.1 | 15.8±5.6 | 10.4±2.1 |
Eosinophil (mean, %) | 8.7±2.8 | 11.3±7.1 | 14.5±9.0 | 5.3±3.4 |
Eosinophilia rate | 70.6 | 66.7 | 57.1 | 15.4 |
Pulmonary function test | ||||
FVC% | 89.6±1.7 | 93.86±4.3 | 93.0±1.8 | 95.86±2.5 |
FEV1% | 83.5±2.2 | 93.14±4.3 | 94.7±2.1 | 97.03±2.3 |
FEV1/FVC% | 79.2±1.4 | 84.29±1.3 | 86.6±1.4 | 86.08±0.8 |
Methacholine provocation | ||||
PC20 (mg/mL)** | 5.3±0.8 | 11.1±1.0 | ||
Exercise provocation test | ||||
Decrement of FEV1 (%) | 32.6±1.7 | 6.93±1.1 | 24.6±2.1 | 7.40±0.7 |
Air pollution | ||||
SO2 | 0.0072±0.0004 | 0.0076±0.0008 | 0.0071±0.0007 | 0.0070±0.0004 |
CO2 | 0.0375±0.0021 | 0.0324±0.0025 | 0.0354±0.0030 | 0.0367±0.0021 |
CO | 0.68±0.06 | 0.47±0.06 | 0.68±0.35 | 0.62±0.23 |
O3 | 0.015±0.002 | 0.016±0.002 | 0.020±0.033 | 0.022±0.019 |
Fine dust | 51.36±3.35 | 54.43±10.05 | 50.15±19.06 | 55.63±28.93 |
Data are means ± SEM or percentages, MBPT: methacholine bronchial provocation test; EIB: exercise provocation test.
indicates p<0.05 between EIB(+) and EIB(−) patients among MBPT(−) patients.
indicates p<0.05 between EIB(+) and EIB(−) patients among MBPT(+) patients.