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. 2014 Jan 30;9(1):e87205. doi: 10.1371/journal.pone.0087205

Figure 6. Accumulation of acylcarnitines and effects on oxidative metabolism in Intralipid®-treated hearts.

Figure 6

Panel A: Accumulation of long-chain acylcarnitines in hearts reperfused for 3 min and 30 min. Panel B: Lack of competition for β-oxidation between exogenous radiolabeled palmitate and fatty acid constituents released from Intralipid® and no alteration in glucose oxidation (Randle cycle). AER, time-matched aerobically perfused hearts. AER/IL, time-matched aerobically perfused hearts treated with 1% Intralipid® for 30 min. IR 3′ or 30′, untreated hearts exposed to 15 min of ischemia and 3 or 30 min of reperfusion, respectively. IR/IL 3′ or 30′, hearts exposed to 15 min of ischemia and 3 or 30 min of reperfusion and 1% Intralipid® at the onset of reperfusion. *, significantly different from the corresponding untreated group. Data are mean (SEM). N = 6 hearts in each group.