Skip to main content
. 2014 Jan 30;9(1):e87548. doi: 10.1371/journal.pone.0087548

Figure 3. d8-Taurocholate (d8-TCA) biliary efflux (A) and clearance (B) in sandwich-cultured human hepatocytes exposed to ambrisentan, bosentan, and macitentan.

Figure 3

The biliary excretion index (BEI) of d8-TCA was largely unaffected by the test ERAs. Bosentan and macitentan treatment resulted in dose-dependent reductions in biliary clearance (Clb) of d8-TCA. Data presented as mean (±SD) expressed as percent of control treated; n = 3 donors; *P<0.05 bosentan vs. control; #P<0.05 macitentan vs. control.