Table 2. Top 20 replicated metabolites, logistic regression.

Metabolite	Class	RoCI β	Roci P value	CAPSOD β	CAPSODP value
1-arachidonoyl-GPE (20:4)	Lipid	−1.51	0.0001	−0.41	0.0142
3-(4-hydroxyphenyl) lactate (HPLA)	Amino acid	1.09	0.0003	0.86	1.3E−05
5taurochenodeoxycholate	Lipid	0.59	0.0007	0.22	0.0028
taurocholate	Lipid	0.48	0.0015	0.21	0.0077
gamma-glutamylphenylalanine	Peptide	1.59	0.0017	0.61	0.0272
glycochenodeoxycholate	Lipid	0.58	0.0020	0.19	0.0114
1-arachidonoyl-GPC (20:4)	Lipid	−0.56	0.0032	−0.30	0.0016
glycocholate	Lipid	0.53	0.0036	0.18	0.0259
Hydroxyisovaleroyl-carnitine (C5)	Amino acid	0.79	0.0041	0.40	0.0317
hexanoylcarnitine (C6)	Lipid	1.15	0.0053	0.97	6.6E−05
lactate	Carbohydrate	1.11	0.0071	0.69	0.0084
alpha-hydroxyisovalerate	Amino acid	0.72	0.0071	0.58	3.8E−04
1-methylimidazoleacetate	Amino acid	0.63	0.0082	0.38	0.0104
isobutyrylcarnitine (C4)	Amino acid	0.71	0.0095	0.34	0.034
beta-hydroxyisovalerate	Amino acid	0.83	0.0134	0.37	0.0364
kynurenate	Amino acid	0.46	0.0137	0.37	0.0494
2-methylbutyroylcarnitine (C5)	Amino acid	0.75	0.0142	0.59	0.0024
1-linoleoyl-GPC (18:2)	Lipid	−0.42	0.0155	−0.30	0.0162
propionylcarnitine (C3)	Lipid	0.90	0.0156	0.62	0.0013
cortisol	Lipid	0.62	0.0175	0.56	0.0118

β and p values shown are for results for association with 28-day mortality, using logistic regression, after adjustment for age, gender, race, malignancy status, and GFR. CAPSOD p values are 1-sided, only metabolites with consistent direction were considered replication. Metabolite levels were log₂ transformed for analysis. Data for all 31 replicated metabolites are shown in Supplemental Table S2.