Table 2. Localisation of the large and small binding pocket relative to PO₄ and O3’ of PLP and binding of the substrates’ substituents in different amino acid and amine transaminases (upper part: fold I aminotransferases, lower part: fold IV aminotransferases).

	Large binding pocketa			Small binding pocketa
	local	substituent		local	substituent
L-AroAATA ( S ) and L-AspTA ( S )	PO4	bulky or γ-carboxylate		O3’	α-carboxylate
( S )-amine TA/L-Ala	O3’	bulky or α-carboxylate		PO4	methyl
D-ATA ( R )	PO4	alkyl or γ-carboxylate		O3’	α-carboxylate
L-BCAT ( S )	O3’	bulky or γ-carboxylate		PO4	α-carboxylate
( R )-amine TA/D-Ala b	O3’	bulky or α-carboxylate		PO4	methyl
AT-ωTA/L-Glu c	O3’		γ-carboxylate	PO4	α-carboxylate

^adefined by the substrate size, in some structures the actual difference in the size of the pockets is very subtle.

^bproposed binding as seen in the scheme in Figure 6.

^cas observed in the solved structure of AT-ωTA.