Table 1. Gene expression profile in human subcutaneous adipocytes.
| Rank | Rosiglitazone (probe set 74) | P value | E value | Pop Hits | Enrich |
| 1 | regulation of cell-cell adhesion involved in gastrulation | 4.70E-05 | 1.41E-04 | 3 | 167.0 |
| 2 | regulation of heterotypic cell-cell adhesion | 4.70E-05 | 1.41E-04 | 3 | 167.0 |
| 3 | regulation of gastrulation | 4.70E-05 | 1.41E-04 | 3 | 167.0 |
| 4 | positive regulation of cholesterol storage | 1.60E-04 | 8.00E-04 | 5 | 100.2 |
| 5 | positive regulation of lipid storage | 5.50E-04 | 4.95E-03 | 9 | 55.7 |
| 6 | negative regulation of I-kappaB kinase/NF-kappaB cascade | 5.50E-04 | 4.95E-03 | 9 | 55.7 |
| 7 | regulation of cholesterol storage | 8.40E-04 | 9.24E-03 | 11 | 45.5 |
| 8 | regulation of embryonic development | 1.20E-03 | 1.56E-02 | 13 | 38.5 |
| 9 | positive regulation of foam cell differentiation | 1.20E-03 | 1.56E-02 | 13 | 38.5 |
| 10 | regulation of glutamate secretion | 1.20E-03 | 1.56E-02 | 13 | 38.5 |
| 11 | regulation of fatty acid biosynthetic process | 1.60E-03 | 2.40E-02 | 15 | 33.4 |
| 12 | negative regulation of endocytosis | 1.60E-03 | 2.40E-02 | 15 | 33.4 |
| 13 | response to vitamin D | 1.80E-03 | 2.88E-02 | 16 | 31.3 |
| 14 | lipid storage | 2.30E-03 | 4.14E-02 | 18 | 27.8 |
| 15 | social behavior | 2.60E-03 | 4.94E-02 | 19 | 26.4 |
| KDT501 (probe set 24) | |||||
| 1 | response to hormone stimulus | 1.50E-05 | 5.51E-03 | 367 | 10.5 |
| 2 | response to endogenous stimulus | 2.60E-05 | 1.05E-02 | 405 | 9.5 |
| 3 | brown fat cell differentiation | 6.20E-04 | 1.49E-02 | 24 | 53.7 |
| 4 | response to steroid hormone stimulus | 1.90E-04 | 3.65E-02 | 192 | 13.4 |
| 5 | fatty acid metabolic process | 2.20E-04 | 4.36E-02 | 198 | 13.0 |
| Telmisartan (probe set 8) | |||||
| 1 | brown fat cell differentiation | 8.80E-03 | 1.08E-03 | 24 | 187.9 |
| 2 | fat cell differentiation | 1.90E-02 | 1.17E-02 | 53 | 85.1 |
| 3 | fatty acid metabolic process | 2.10E-03 | 1.19E-02 | 198 | 34.2 |
| 4 | response to drug | 2.50E-03 | 1.66E-02 | 216 | 31.3 |
| 5 | regulation of inflammatory response | 2.80E-02 | 3.50E-02 | 76 | 59.3 |
| 6 | response to glucocorticoid stimulus | 2.90E-02 | 3.74E-02 | 78 | 57.8 |
| 7 | response to corticosteroid stimulus | 3.10E-02 | 4.93E-02 | 85 | 53.1 |
Gene expression fold-change with test compounds larger than 1 log2 ratio (±1) over control with a p-value (Fisher exact) <0.05 and PADE value <15. The Bonferroni adjusted p-value (<0.05) was used for ranking and is shown as “E-Value”. The GO terms for KDT501 (probe set 24), rosiglitazone (probe set 74) and telmisartan (probe set 8) denote direct biological pathways.