Table 5.
Culture | Antibacterial effect of Bacteriocins when used alone | ADDITIVE | SYNERGISTIC | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Incubation Time | Control | N | P | E | N+P | N+E | E+P | N+P+E | N+P | N+E | E+P | N+P+E | |
E. faecalis ATCC 29212 | 1 h | 8.4 ± 0.01a,m | 4.6 ± 0.06a,n | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
2 h | 8.4 ± 0.03b,m | 4.0 ± 0.01b,n | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
4 h | 8.2 ± 0.07c,m | 5.9 ± 0.03c,n | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
6 h | 8.3 ± 0.01d,m | 5.8 ± 0.09d,n | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
24 h | 8.2 ± 0.07e,m | 2.3 ± 0.03e,n | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
L. monocytogenes MTCC 657 | 1 h | 7.6 ± 0.09a,m | 6.9 ± 0.09a,n | 5.7 ± 0.06a,o | 6.8 ± 0.07a,p | 5.3 ± 0.04a,q | 4.8 ± 0.11a,r | 3.0 ± 0.05a,s | 6.0 ± 0.10a,t | 3.8 ± 0.04a,u | 3.4 ± 0.05a,v | 2.3 ± 0.03a,w | 3.4 ± 0.05a,x |
2 h | 7.5 ± 0.07b,m | 6.9 ± 0.07b,n | 5.9 ± 0.04b,o | 6.5 ± 0.07b,p | 5.2 ± 0.03b,q | 5.2 ± 0.09b,r | 3.6 ± 0.22b,s | 5.0 ± 0.12b,t | 3.9 ± 0.08b,u | 4.3 ± 0.09b,v | 2.3 ± 0.09b,w | 3.5 ± 0.07b,x | |
4 h | 7.6 ± 0.07c,m | 7.0 ± 0.07c,n | 5.3 ± 0.03c,o | 7.3 ± 0.09c,p | 5.7 ± 0.11c,q | 5.3 ± 0.12c,r | 3.9 ± 0.05c,s | 7.0 ± 0.14c,t | 3.6 ± 0.09c,u | 4.0 ± 0.09c,v | 2.4 ± 0.09c,w | 4.1 ± 0.05c,x | |
6 h | 8.6 ± 0.09d,m | 6.8 ± 0.09d,n | 6.1 ± 0.03d,o | 7.5 ± 0.07d,p | 6.0 ± 0.10d,q | 4.0 ± 0.13d,r | 3.8 ± 0.09d,s | 7.8 ± 0.16d,t | 4.3 ± 0.03d,u | 2.9 ± 0.08d,v | 2.1 ± 0.05d,w | 4.5 ± 0.01d,x | |
24 h | 7.1 ± 0.15e,m | 6.8 ± 0.15e,m | 5.6 ± 0.03e,o | 6.4 ± 0.05e,p | 5.1 ± 0.15e,q | 4.2 ± 0.21e,r | 2.4 ± 0.18e,s | 4.3 ± 0.18e,t | 4.5 ± 0.04e,u | 4.5 ± 0.09e,v | 2.0 ± 0.02e,w | 3.9 ± 0.09e,x | |
E. faecium DSMZ 20477 | 1 h | 6.9 ± 0.04a,m | 5.8 ± 0.09a,n | 6.7 ± 0.02a,m | 6.1 ± 0.04a,p | 6.8 ± 0.05a,m | 6.2 ± 0.09a,r | 6.5 ± 0.02a,s | 5.5 ± 0.015a,t | 3.0 ± 0.09a, u | 4.6 ± 0.09a,v | 4.6 ± 0.05a,w | 2.3 ± 0.03a,x |
2 h | 8.2 ± 0.01b,m | 6.5 ± 0.03b,n | 6.9 ± 0.09b,o | 7.3 ± 0.03b,p | 6.8 ± 0.09b,q | 6.1 ± 0.09b,r | 5.3 ± 0.03b,s | 4.9 ± 0.08b,t | 3.3 ± 0.03b,u | 3.4 ± 0.05b,v | 4.4 ± 0.05b,w | 2.3 ± 0.01b,x | |
4 h | 7.6 ± 0.08c,m | 7.4 ± 0.07c,m | 7.6 ± 0.09c,m | 7.3 ± 0.03c,m | 7.0 ± 0.02c,q | 6.9 ± 0.09c,r | 6.0 ± 0.09c,s | 5.3 ± 0.03c,t | 3.0 ± 0.05c,u | 3.3 ± 0.09c,v | 5.4 ± 0.09c,w | 2.2 ± 0.05c,x | |
6 h | 8.5 ± 0.04d,m | 5.7 ± 0.08d,n | 7.4 ± 0.06d,o | 8.3 ± 0.06d,p | 7.1 ± 0.04d,q | 6.1 ± 0.04d,r | 7.3 ± 0.03d,s | 6.2 ± 0.12d,t | 5.3 ± 0.03d,u | 4.0 ± 0.06d,v | 6.3 ± 0.04d,w | 3.0 ± 0.02d,x | |
24 h | 8.9 ± 0.09e,m | 8.0 ± 0.03e,n | 8.4 ± 0.03e,o | 8.5 ± 0.02e,p | 8.3 ± 0.03e,q | 8.3 ± 0.09e,r | 8.2 ± 0.02e,s | 7.3 ± 0.03e,t | 5.3 ± 0.03e,u | 5.0 ± 0.05e,v | 7.6 ± 0.05e,w | 2.3 ± 0.06e,x | |
E. faecium VRE | 1 h | 5.1 ± 0.21a,m | 3.2 ± 0.04a,n | 3.4 ± 0.09a,o | 4.3 ± 0.06a,p | 2.4 ± 0.11a,q | 3.4 ± 0.22a,r | 5.3 ± 0.12a,s | 2.8 ± 0.11a,t | 2.3 ± 0.03a,u | 2.6 ± 0.09a,v | 3.6 ± 0.09a,w | 1.6 ± 0.06a,x |
2 h | 6.8 ± 0.03b,m | 2.4 ± 0.02b,n | 5.6 ± 0.03b,o | 5.3 ± 0.04b,p | 2.7 ± 0.22a,q | 2.1 ± 0.14b,r | 4.6 ± 0.08b,s | 1.6 ± 0.10b,t | 2.8 ± 0.09b,u | 2.3 ± 0.01b,v | 2.4 ± 0.09b,w | 1.4 ± 0.06b,x | |
4 h | 6.2 ± 0.12c,m | 2.9 ± 0.05c,n | 4.1 ± 0.05c,o | 4.9 ± 0.05c,p | 4.0 ± 0.23a,q | 2.3 ± 0.04c,r | 4.4 ± 0.07c,s | 2.6 ± 0.19c,t | 3.1 ± 0.01c,u | 2.0 ± 0.03c,v | 2.3 ± 0.09c,w | 2.0 ± 0.09c,x | |
6 h | 9.2 ± 0.02d,m | 5.0 ± 0.03d,n | 4.4 ± 0.09d,o | 7.0 ± 0.12d,p | 4.5 ± 0.31a,q | 4.1 ± 0.13d,r | 4.3 ± 0.12d,s | 3.1 ± 0.02d,t | 3.5 ± 0.02d,u | 2.2 ± 0.03d,v | 2.7 ± 0.02d,w | 2.1 ± 0.02d,x | |
24 h | 8.3 ± 0.07e,m | 5.4 ± 0.03e,n | 3.4 ± 0.07e,o | 3.6 ± 0.08e,p | 5.0 ± 0.12a,q | 4.1 ± 0.02d,r | 7.3 ± 0.03e,s | 3.0 ± 0.21e,t | 2.4 ± 0.12e,u | 2.1 ± 0.02e,v | 2.4 ± 0.05e,w | 1.6 ± 0.09e,x |
Values are mean±SE of three independent determinations (n = 3); ND Not detected. Values with different alphaphets, (a,b,c.d,e for incubation time and m,n,o,p,q,r,s,t,u,v,w,x for different bacteriocin treatments) are statistically significant (P < 0.05)