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a Kinetic analysis of the PDE1 activity and the mode of inhibitory action of both compounds was examined using the Lineweaver–Burk plot method. Inhibition was performed with 5 μM tehranolide and 5 μM artemisinin in varying concentrations of cAMP (calmodulin concentration in all the reactions was constant, 100 μM). b Dixon plots: Inhibition was performed with varying concentrations of artemisinin and tehranolide
