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. 2014 Jan 31;8:23. doi: 10.3389/fncel.2014.00023

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Copyright © 2014 Martin and Manzoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AMPA—NMDA ratio is increased in adult but not adolescent VPA mPFC neurons. (A) Example EPSCs recorded from visually identified pyramidal neurons in layer V/VI mPFC from adolescent rats (P45–P49). Negative traces represent inward evoked currents from neurons patch-clamped at −70 mV, positive traces represent outward evoked currents from neurons patch-clamped at +40 mV. Scale bar 50 ms, 100 pA. (B) Average AMPA/NMDA ratio from adolescent rats exposed to saline or VPA in utero. (C) Similar evoked example EPSC traces from visually identified deep layer pyramidal neurons from adult rats (P110–P130). (D) Average AMPA/NMDA ratio from adult rats exposed to saline or VPA in utero. Data points represent AMPA/NMDA ratio from individual animals. Data shown as mean ± s.e.m.; * p < 0.05.