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. 2014 Jan 31;8:23. doi: 10.3389/fncel.2014.00023

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Copyright © 2014 Martin and Manzoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Basal synaptic activity is normal in adult VPA neurons. (A) Input—Output relationships derived from evoked fEPSPs in deep layer mPFC. Sample fEPSP traces from saline and VPA treated rats showing fEPSP change in response to 10 pA stimulation steps (top). Scale bar 10 ms, 0.5 mV. Average fEPSP amplitude from saline and VPA neurons (bottom). (B) Spontaneous EPSCs from pyramidal neurons patch-clamped at −70 mV. Scale bar 0.5 s, 10 pA. (C) Cumulative probability plot of individual spontaneous EPSCs from adult saline and VPA neurons. Average amplitude EPSC from individual animals (insert; Saline, n = 5; VPA, n = 7). (D) Cumulative probability plot of intervals between spontaneous EPSC events from saline and VPA neurons. Average recorded interval between spontaneous events from individual neurons (insert). Data shown as mean ± s.e.m.