Table 2.
Antiproliferative activity of WT1-pTj on WT1-expressing tumor cell lines and nontumor forming cell lines.
| Cell lines | EC50a (mol/l x 10−3) |
|---|---|
| A2058 human melanoma | 0.455 ± 0.032 |
| SK-MEL-28 human melanoma | 0.680 ± 0.020 |
| B16F10-Nex2 murine melanoma | 0.466 ± 0.067 |
| MCF-7 human breast cancer | 0.247 ± 0.058 |
| MDA-MB231 human breast cancer | 0.759 ± 1.40 |
| OVCAR-3 human ovarian cancer | 0.208 ± 0.02 |
| HL-60 human acute leukemia | >1 |
| HFF human foreskin fibroblast | >1 |
| MEF murine embryonic fibroblast | >1 |
a
EC50 is the concentration that decreases viability by 50% in a dose-dependent survival curve.