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. 2014 Jan 31;5:14. doi: 10.3389/fpls.2014.00014

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Copyright © 2014 Lang and Faure.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representation of the sophisticated hierarchical QS regulation in A. tumefaciens strain C58. QS-dependent conjugation and copy-number amplification of the Ti plasmid is initiated when OC8HSL and TraR reach appropriate concentration and form transcriptional active dimers. QS-signaling is positively regulated by the conjugal opines agrocinopines which are produced by the transformed plant cells (1) and induce production of TraR by releasing AccR repressive action (2). Then, active TraR-OC8HSL dimers activate the production of TraI, thereby triggering a positive feedback in the synthesis of OC8HSLs (3) which are diffusible molecules (4). The QS activation is delayed by the TraR-antagonist TraM (5), as well as OC8HSL-cleaving lactonases AiiB and AttM (6) whose expressions are controlled by agrocinopines and GABA, respectively. SAM, S-adenosylmethionine; ACP, acyl carrier protein. The Ti plasmid genes and the At plasmid genes are in blue and pink boxes, respectively.