Table 1.
PK profile in in vivo study.
| Inducer | Dose (mg/kg) | Day | AUC (1) (Ratio to Day 0) (ng/mL·h) | T1/2 (h) | Cmax (1) (ng/mL) | Tmax (h) |
|---|---|---|---|---|---|---|
| 3-MC | 2 | 0 | 44.2 ± 0.0 | 2.1 | 7.4 ± 0.0 | 2.0 |
| - | 3 | 0.0 ± 0.0 (0.0) | - | - | - | |
| 20 | 0 | 94.4 ± 20.8 | 8.6 | 12.2 ± 4.3 | 2.0 | |
| - | 3 | 35.4 ± 21.3 ** (0.4) | 9.1 | 2.4 ± 0.3 | 2.0 | |
|
| ||||||
| Rifampicn | 0.1 | 0 | 236.8 ± 76.6 | 3.1 | 45.0 ± 19.2 | 0.5 |
| - | 3 | 154.9 ± 47.6 (0.7) | 3.5 | 24.1 ± 8.7 | 0.5 | |
| 10 | 0 | 40,186.5 ± 9,088.3 | 3.0 | 6,926.0 ± 4,653.4 | 0.5 | |
| - | 3 | 22,125.3 ± 6,222.4 (0.6) | 2.0 | 5,353.3 ± 1,122.5 | 1.0 | |
(1)
mean ± S.D.;
**
p < 0.01.