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. 2014 Jan 6;15(1):560–573. doi: 10.3390/ijms15010560

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© 2014 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Representative in situ hybridization (A) and immunohistochemistry (B) images respectively for miR-340 and ROCK1 protein expression in osteosarcoma and corresponding noncancerous bone tissues (Original magnification ×200); Compared with the corresponding noncancerous bone tissues, the expression level of miR-340 (mean ± S.D.: 2.69 ± 1.01 vs. 4.11 ± 1.36, p < 0.001) (C) was significantly decreased, while the expression level of ROCK1 protein (mean ± S.D.: 1.40 ± 0.83 vs. 3.74 ± 1.25, p < 0.001) (D) was significantly increased in osteosarcoma tissues.