Table 2.
Multivariate survival analysis of overall survival and progression-free survival in 92 patients with pediatric osteosarcoma.
| Variables | Overall survival | Progression-free survival | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| RR | 95% CI | p | RR | 95% CI | p | |
| miR-340 expression | 6.2 | 1.4–13.9 | 0.006 | 4.5 | 1.0–9.2 | 0.01 |
| ROCK1 expression | 5.8 | 1.2–12.6 | 0.008 | 3.2 | 1.0–8.8 | 0.02 |
| miR-340/ROCK1 expression | 7.6 | 1.5–16.2 | 0.002 | 6.5 | 1.0–8.2 | 0.005 |
| Tumor size | 3.5 | 1.0–8.4 | 0.01 | 2.9 | 0.8–7.6 | 0.02 |
| Metastasis status | 4.2 | 1.6–10.3 | 0.006 | 3.9 | 1.3–9.6 | 0.008 |
| Response to pre-operative chemotherapy | 2.5 | 0.9–7.3 | 0.02 | 2.1 | 0.6–6.6 | 0.03 |