Table 1.

Parameters used for electrospinning and details of the nanofiber products.

No.	Process	Drug con. (w/v)		Flow rate (mL/h)		Morphology c	Total drug content d	Diameter (nm)
		Shell a	Core b	Shell	Core
F1	Single	-	3%	-	1.0	Linear	11.11%	570 ± 140
F2		5%	-	1.0	-	-	-	-
F3	Coaxial	5%	3%	0.3	1.0	Linear	13.64%	930 ± 170
F4		5%	6%	0.3	1.0	Linear	20.83%	910 ± 220
F5		5%	6%	0.3	0.5	Mixed	-	-

^aShell fluid consists of 15% (w/v) PVP K25 and a fixed APAP concentration of 5% (w/v) in a mixture of ethanol and DMAc (8:2, v:v);

^bCore fluid consists of 24% (w/v) EC and a varied concentration of APAP in ethanol;

^c“Linear” morphology refers to nanofibers with few beads or spindles and “Mixed” morphology to nanofibers exhibiting beads-on-a-string or spindles-on-a-string features;

^dThe theoretical value (w/w) in the solid nanofibers calculated according to the shell and core fluid flow rates and the drug content in the shell and core solutions.