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. 2014 Jan 20;15(1):1402–1417. doi: 10.3390/ijms15011402

Figure 3.

Figure 3.

(a) Phenoxybenzamine, delivered 8 h after a severe traumatic brain injury (TBI) significantly reduced neurological impairment. PBZ at 1.0 mg/kg was delivered 8 h after a severe TBI. At 24 h and 7 days post-injury there was no significant difference in neurological impairment. Beginning on day 14 post-injury, significant differences in neurological severity scores were observed. This trend continued on day 21 and day 30 post-injury with significant differences observed between PBZ treated injured animals and saline treated injured animals. * p < 0.05, *** p < 0.001, n = a minimum of nine animals. (b) Phenoxybenzamine, delivered 8 hours after a severe TBI, significantly reduced foot fault errors. PBZ at 1.0 mg/kg was delivered 8 h after a severe TBI. At 24 h and 7 days post-injury there was no significant difference in foot fault errors. Beginning on day 14 post-injury, significant differences in foot fault errors was observed. This trend continued on day 21 and day 30 post-injury with significant differences observed between PBZ treated injured animals and saline treated injured animals. ** p < 0.01, n = 13 for saline treated TBI; n = 9 for phenoxybenzamine treated TBI animals; n = 8 for surgical shams.