Table 1.
Weight gain and liver percentage relative to body weight in rats with cholesterol-rich diet, atorvastatin and with or without coenzyme Q 10 supplementation
| CD | CD + ATV 2 (0.56 /day) | HD | HD + ATV 1 (0.2 g/day) | HD + ATV 2 (0.56 mg/day) | HD + ATV 3 (1.42 mg/day) | |
|---|---|---|---|---|---|---|
| Body weight gain (g) |
|
|
|
|
|
|
| Without CoQ10 |
114 ± 20 |
126 ± 23 |
140 ± 4ª |
130 ± 7 |
135 ± 24 |
104 ± 38 |
| With CoQ10 |
95 ± 71 |
102 ± 361 |
117 ± 8a,1 |
77 ± 28b,1 |
108 ± 61 |
96 ± 8b,1 |
| Liver percentage |
|
|
|
|
|
|
| Relative to body weight (%) |
|
|
|
|
|
|
| Without CoQ10 |
2.9 ± 0.2 |
2.7 ± 0.1a |
4.7 ± 1.3a |
4.5 ± 0.3 |
4.3 ± 0.3 |
4.3 ± 0.5 |
| With CoQ10 | 2.38 ± 0.11 | 3.2 ± 0.1a, 1 | 3.92 ± 1.1a | 3.9 ± 0.11 | 3.08 ± 0.13b, 1 | 3.2 ± 0.18b, 1 |
CD, control diet; CD + ATV2, CD + atorvastatin 0.56 mg/day; HD, hypercholesterolemic diet; HD + ATV1, 0.2 mg/day; HD + ATV2 0.56 mg/day; HD + ATV3 1.42 mg/day, Coenzyme Q10, 0.57 mg/day; Data are expressed as mean ± S.E.M.; n = 8. One-way analysis of variance (ANOVA) (groups CD, CD + ATV2, HD, HD + ATV1, HD + ATV2, HD + ATV3) accompanied by the Student-Newman-Keuls test and differences between the groups were determined by the Student's t test (Without CoQ10 vs With CoQ10) (p < 0.05). aStatistically different from CD (p < 0.05); bstatistically different from either HD or HD + CoQ10 (p < 0.05); 1statistically different from the same group without CoQ10.