Table 3.
Effect of CoQ 10 supplementation on liver cholesterol and triacylglycerols of rats with a cholesterol-rich diet and atorvastatin
| |
CD |
CD + ATV
2
|
HD |
HD + ATV
1
|
HD + ATV
2
|
HD + ATV
3
|
|---|---|---|---|---|---|---|
| (0.56 mg/day) | (0.2 mg/day) | (0.56 mg/day) | (1.42 mg/day) | |||
| TC |
|
|
|
|
|
|
| Without CoQ10 |
2.71 ± 0.86 |
2.77 ± 0.33 |
12.43 ± 2.84a |
7.80 ± 1.73b |
8.71 ± 0.62b |
7.38 ± 1.15b |
| With CoQ10 |
2.30 ± 0.75 |
1.87 ± 0.34a,1 |
6.42 ± 0.86a,1 |
2.42 ± 0.47b,1 |
2.25 ± 0.46b,1 |
3.30 ± 0.75b,1 |
| TAG |
|
|
|
|
|
|
| Without CoQ10 |
5.58 ± 0.88 |
7.53 ± 0.45a |
10.66 ± 0.33a |
9.73 ± 1.95 |
9.70 ± 1.50 |
6.31 ± 2.23b |
| With CoQ10 | 4.30 ± 0.551 | 6.24 ± 1.16a,1 | 10.70 ± 0.32a | 3.73 ± 0.60b,1 | 2.81 ± 0.11b, 1 | 6.47 ± 0.20b |
CD, control diet; CD + ATV2, CD + atorvastatin 0.56 mg/day; HD, hypercholesterolemic diet; HD + ATV1, 0.2 mg/day; HD + ATV2 0.56 mg/day; HD + ATV3 1.42 mg/day, Coenzyme Q10, 0.57 mg/day; Data are expressed as mean ± S.E.M.; n = 8. One-way analysis of variance (ANOVA) (groups CD, CD + ATV2, HD, HD + ATV1, HD + ATV2, HD + ATV3) accompanied by the Student-Newman-Keuls test and differences between the groups were determined by the Student's t test (Without CoQ10 vs With CoQ10) (p < 0.05). aStatistically different from either CD or CD + CoQ10 (p < 0.05); bstatistically different from either HD or HD + CoQ10 (p < 0.05); 1statistically different from the same group without CoQ10.