Table 4.
Effect of a cholesterol-rich diet and atorvastatin with or without coenzyme Q 10 supplementation on the liver mitochondrial respiratory control index
|
Respiratory control |
CD |
CD + ATV
2
|
HD |
HD + ATV
1
|
HD + ATV
2
|
HD + ATV
3
|
|---|---|---|---|---|---|---|
| (0.56 mg/day) | (0.2 mg/day) | (0.56 g/day) | (1.42 mg/day) | |||
| Without CoQ10 |
2.98 ± 0.06 |
2.25 ± 0.25a |
2.02 ± 0.51a |
2.93 ± 0.27b |
1.85 ± 0.15 |
2.38 ± 0.35 |
| With CoQ10 | 3.20 ± 0.151 | 4.69 ± 0.27a,1 | 3.68 ± 0.21a,1 | 2.72 ± 0.40b | 3.55 ± 0.021 | 3.13 ± 0.221 |
CD, control diet; CD + ATV2, CD + atorvastatin 0.56 mg/day; HD, hypercholesterolemic diet; HD + ATV1, 0.2 mg/day; HD + ATV2 0.56 mg/day; HD + ATV3 1.42 mg/day, Coenzyme Q10, 0.57 mg/day; Data are expressed as mean ± S.E.M.; n = 8. One-way analysis of variance (ANOVA) (groups CD, CD + ATV2, HD, HD + ATV1, HD + ATV2, HD + ATV3) accompanied by the Student-Newman-Keuls test and differences between the groups were determined by the Student's t test (Without CoQ10 vs With CoQ10) (p < 0.05). aStatistically different from either CD or CD + CoQ10 (p < 0.05); bstatistically different from either HD or HD + CoQ10 (p < 0.05); 1statistically different from the same group without CoQ10.