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Binding and Cell Activation by Conjugates
| competitor | avidity: Kd (nM) | cell activation: EC50 (nM) | relative avidity: Kd × no. of fMLF | avidity/activation: EC50/Kd |
|---|---|---|---|---|
| fMLF | 28 | 4.7 | 28 | 0.168 |
| B8-PEG–fMLF1.1 | 190 | – | 209 | – |
| B3-PEG–fMLF3 | 1.9 | 9.6 | 5.7 | 5.05 |
| B4-PEG–fMLF4 | 0.8 | 5.0 | 3.2 | 6.25 |
| B8-PEG–fMLF5.5 | 0.5 | 5.3 | 2.75 | 10.6 |
| B8-PEG–fMLF8 | 0.18 | 5.0 | 1.44 | 27.8 |
| PEG/A–fMLF4 | 1.1 | ND | 4.4 | – |
| PEG/A–fMLF4–DIG4 | 1.2 | 5.9 | 4.8 | 4.92 |
